{"id":896,"date":"2012-05-08T20:16:05","date_gmt":"2012-05-08T18:16:05","guid":{"rendered":"http:\/\/slanedeti.sk\/cms\/antibiotika-pri-cystickej-fibroze-studia-prinasa-nove-otazky-2\/201205"},"modified":"2014-01-04T19:42:55","modified_gmt":"2014-01-04T18:42:55","slug":"antibiotika-pri-cystickej-fibroze-studia-prinasa-nove-otazky-2","status":"publish","type":"post","link":"https:\/\/slanedeti.sk\/cms\/antibiotika-pri-cystickej-fibroze-studia-prinasa-nove-otazky-2\/896","title":{"rendered":"Antibiotik\u00e1 pri cystickej fibr\u00f3ze: \u0160t\u00fadia prin\u00e1\u0161a nov\u00e9 ot\u00e1zky"},"content":{"rendered":"

Desa\u0165ro\u010die prebiehaj\u00faca \u0161t\u00fadia na University of Michigen zistila, \u017ee pri lie\u010dbe cystickej fibr\u00f3zy nemus\u00ed by\u0165 s\u00fa\u010dasn\u00fd \u0161tandard agres\u00edvnej antibiotickej lie\u010dby najlep\u0161\u00edm rie\u0161en\u00edm.<\/p>\n

Tradi\u010dne s\u00fa na potla\u010denie p\u013e\u00facnych infekci\u00ed CF pacientov, pou\u017e\u00edvan\u00e9 ve\u013emi siln\u00e9 antibiotik\u00e1, s cie\u013eom potla\u010di\u0165 popul\u00e1ciu bakt\u00e9ri\u00ed na najni\u017e\u0161iu mo\u017en\u00fa \u00farove\u0148,\u00a0 ale autor \u0161t\u00fadie Dr. John\u00a0 LiPuma tvrd\u00ed, \u017ee\u00a0 zachovanie bakteri\u00e1lnej diverzity m\u00f4\u017ee niektor\u00fdm pacientom pom\u00f4c\u0165 zosta\u0165 dlh\u0161ie zdrav\u00fdmi.<\/p>\n

Tieto zistenia boli publikovan\u00e9 v Proceedings of the National Academy of Sciences.<\/p>\n

\"201205082003_atb_priCF\"<\/div>\n

\u201cKonven\u010dn\u00e9 poznanie je, \u017ee ako sa so zvy\u0161uj\u00facim vekom stav CF pacientov zhor\u0161uje, s\u00fa po\u010das progresie ochorenia p\u013e\u00faca kolonizovan\u00e9 st\u00e1le v\u00e4\u010d\u0161\u00edm mno\u017estvom bakt\u00e9rii\u201c hovor\u00ed LiPuma, v\u00fdskumn\u00fd profesor pediatrick\u00fdch a prenosn\u00fdch ochoren\u00ed na University of Michigan Medical School. „Ale na\u0161a \u0161t\u00fadia, ktor\u00e1 je prvou, ktor\u00e1 sk\u00fama bakteri\u00e1lne os\u00eddlenie v p\u013e\u00facach CF pacientov po\u010das dlh\u00e9ho \u010dasov\u00e9ho obdobia, nazna\u010duje, \u017ee sa to nedeje“.<\/p>\n

Miesto toho, agres\u00edvne pou\u017eitie antibiot\u00edk, viac ako vek pacienta, alebo progresia ochorenia je zodpovedn\u00e9 za zn\u00ed\u017eenie diverzity p\u013e\u00facnych bakt\u00e9rii, \u010doho n\u00e1sledkom sa infekcie st\u00e1vaj\u00fa \u0165a\u017eko lie\u010dite\u013en\u00e9. Os\u00eddlenie r\u00f4znymi druhmi bakt\u00e9rii m\u00f4\u017ee vies\u0165 medzi nimi ku konkurencii, ktorej v\u00fdsledkom je, \u017ee rozmno\u017eovanie virulentnej\u0161\u00edch kme\u0148ov je s\u0165a\u017een\u00e9, tvrdia v\u00fdskumn\u00edci.<\/p>\n

LiPuma nazna\u010duje, \u017ee tieto v\u00fdsledky m\u00f4\u017eu by\u0165 prv\u00fdm krokom k nov\u00fdm terapeutick\u00fdm pr\u00edstupom ako viac cielen\u00e9 pou\u017eitie antibiot\u00edk, alebo dokonca probiotick\u00e9mu pr\u00edstupu.<\/p>\n

Cystick\u00e1 fibr\u00f3za je chronick\u00e9, \u017eivot ohrozuj\u00face ochorenie, pri\u010dom pacienti s\u00fa vystaven\u00fd infekci\u00e1m, ktor\u00fdch z\u00e1va\u017enos\u0165 sa postupne zvy\u0161uje. Pri CF je v organizme produkovan\u00fd hust\u00fd, pri\u013enav\u00fd hlien upch\u00e1vaj\u00faci d\u00fdchacie cesty a vytv\u00e1raj\u00faci priestor vhodn\u00fd pre mno\u017eenie bakt\u00e9rii. CF postihuje v Spojen\u00fdch \u0160t\u00e1toch 30 000 \u013eud\u00ed, zvy\u010dajne je diagnostikovan\u00e1 v skorom detstve a v\u010faka medic\u00ednskemu pokroku sa pacienti \u010dasto do\u017e\u00edvaj\u00fa nad 30 a\u017e 40 rokov.<\/p>\n

V\u00fdskumn\u00edci zistili, \u017ee sa celkov\u00e1 miera koloniz\u00e1cie (pribli\u017en\u00e9 celkov\u00e9 mno\u017estvo bakt\u00e9rii) nemen\u00ed, \u010do znamen\u00e1, \u017ee sa zni\u017euje diverzita, skupina bakt\u00e9rii ktor\u00e1 predstavovala p\u00f4vodne mal\u00fd po\u010det sa rozmno\u017e\u00ed a zaujme miesto t\u00fdch, ktor\u00e9 boli zni\u010den\u00e9.<\/p>\n

Predch\u00e1dzaj\u00face \u0161t\u00fadie vych\u00e1dzali zo vzoriek od jednotliv\u00fdch pacientov v jednom \u010dasovom bode, \u010do komplikovalo sk\u00famanie vz\u0165ahu medzi progresiou ochorenia, antibiotickou lie\u010dbou a \u010fal\u0161\u00edmi parametrami, objas\u0148uje LiPuma. T\u00e1to \u0161t\u00fadia sk\u00fama bakteri\u00e1lnu koloniz\u00e1ciu \u0161iestich pacientov po\u010das obdobia \u00f4smych a\u017e deviatych rokov. Traja pacienti mali relat\u00edvne stabiln\u00fd typ ochorenia a traja typickej\u0161iu formu s r\u00fdchlej\u0161ou progresiou. DNA anal\u00fdza sp\u00fata bola uskuto\u010dnen\u00e1 pri 126 vzork\u00e1ch sp\u00fata.<\/p>\n

Vedci boli tie\u017e prekvapen\u00ed, \u017ee exacerb\u00e1cie neboli spojen\u00e9 so \u017eiadnymi \u0161pecifick\u00fdmi zmenami v\u00a0 bakteri\u00e1lnom os\u00eddlen\u00ed. V s\u00fa\u010dasnosti prebieha \u010fal\u0161\u00ed v\u00fdskum, ktor\u00fd sa sna\u017e\u00ed odhali\u0165 sign\u00e1ly, ktor\u00e9 by mohli predch\u00e1dza\u0165 vzplanutiam infekci\u00ed, vysvet\u013euje LiPuma, ktor\u00fd tie\u017e zast\u00e1va post profesora epidemiol\u00f3gie na University of Michigen School of Public Health.<\/p>\n

\u201cPosunutie n\u00e1\u0161ho poznania vz\u0165ahu medzi bakt\u00e9riami v p\u013e\u00facach a progresiou cystickej fibr\u00f3zy je kritick\u00e9 pre v\u00fdvoj nov\u00fdch lie\u010debn\u00fdch postupov a pred\u013a\u017eenie \u017eivota pacientov\u201c dod\u00e1va.<\/p>\n

Medical News Today<\/a>, 28. marca 2012<\/p>\n


\nPozn\u00e1mky prekladate\u013ea
\n<\/strong>
\nVzh\u013eadom na to, \u017ee z\u00e1very tejto zauj\u00edmavej \u0161t\u00fadie, publikovanej v prest\u00ed\u017enom vedeckom \u010dasopise, nepodporuj\u00fa v s\u00fa\u010dasnosti zau\u017e\u00edvan\u00e9 \u0161tandardn\u00e9 klinick\u00e9 postupy CF lie\u010dby, pova\u017eujem za vhodn\u00e9 pripoji\u0165 nieko\u013eko stru\u010dn\u00fdch pozn\u00e1mok. S\u00fa\u010dasn\u00e1 antibiotick\u00e1 lie\u010dba CF vych\u00e1dza z dlhoro\u010dn\u00fdch klinick\u00fdch sk\u00fasenost\u00ed, aj ke\u010f lie\u010dba sa neust\u00e1le zdokona\u013euje a v\u0161etky vedeck\u00fdmi met\u00f3dami z\u00edskan\u00e9 poznatky prin\u00e1\u0161aj\u00fa pokrok. S\u00fa\u010dasn\u00e9 princ\u00edpy antibiotickej lie\u010dby pri CF zatia\u013e neboli in\u00fdmi \u0161t\u00fadiami spochybnen\u00e9. Objekt\u00edvnym nedostatkom tejto \u0161t\u00fadie je, \u017ee zah\u0155\u0148ala iba 6 pacientov, \u010do je pr\u00edli\u0161 m\u00e1lo na formulovanie presved\u010div\u00fdch z\u00e1verov. T\u00e1to \u0161t\u00fadia m\u00f4\u017ee vyvola\u0165 vedeck\u00fa diskusiu, ale rozhodne neprin\u00e1\u0161a dostatok d\u00f4kazov pre zmenu lie\u010debn\u00fdch postupov. V bud\u00facnosti sa d\u00e1 predpoklada\u0165 intenz\u00edvnej\u0161\u00ed v\u00fdskum d\u00f4sledkov pou\u017e\u00edvania antibiot\u00edk a a\u017e na z\u00e1klade zv\u00e1\u017eenia viacer\u00fdch mo\u017enost\u00ed a z\u00e1sadne v\u00e4\u010d\u0161ieho po\u010dtu pacientov m\u00f4\u017ee by\u0165 v bud\u00facnosti d\u00f4vod upravi\u0165 klinick\u00e9 odpor\u00fa\u010dania.
\n<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Desaťročie prebiehajúca štúdia na University of Michigen zistila, že pri liečbe cystickej fibrózy nemusí byť súčasný štandard agresívnej antibiotickej liečby najlepším riešením. Tradične sú na potlačenie pľúcnych infekcií CF pacientov, používané veľmi silné antibiotiká, s cieľom potlačiť populáciu baktérií na … Continued<\/a><\/p>\n","protected":false},"author":7,"featured_media":1185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","footnotes":""},"categories":[3],"tags":[],"class_list":["post-896","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lieky-a-liecba"],"yoast_head":"\nAntibiotik\u00e1 pri cystickej fibr\u00f3ze: \u0160t\u00fadia prin\u00e1\u0161a nov\u00e9 ot\u00e1zky - Slan\u00e9 deti<\/title>\n<meta name=\"description\" content=\"Desa\u0165ro\u010die prebiehaj\u00faca \u0161t\u00fadia na University of Michigen zistila, \u017ee pri lie\u010dbe cystickej fibr\u00f3zy nemus\u00ed by\u0165 agres\u00edvna antibiotick\u00e1 lie\u010dba najlep\u0161\u00edm rie\u0161en\u00edm.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/slanedeti.sk\/cms\/antibiotika-pri-cystickej-fibroze-studia-prinasa-nove-otazky-2\/896\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibiotik\u00e1 pri cystickej fibr\u00f3ze: \u0160t\u00fadia prin\u00e1\u0161a nov\u00e9 ot\u00e1zky - 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