{"id":859,"date":"2010-10-15T07:41:27","date_gmt":"2010-10-15T05:41:27","guid":{"rendered":"http:\/\/slanedeti.sk\/cms\/prevencia-a-liecba-alergickej-reakcie-na-plesen-pomocou-vitaminu-d-2\/201010"},"modified":"2014-02-09T15:54:03","modified_gmt":"2014-02-09T14:54:03","slug":"prevencia-a-liecba-alergickej-reakcie-na-plesen-pomocou-vitaminu-d-2","status":"publish","type":"post","link":"https:\/\/slanedeti.sk\/cms\/prevencia-a-liecba-alergickej-reakcie-na-plesen-pomocou-vitaminu-d-2\/859","title":{"rendered":"Prevencia a lie\u010dba alergickej reakcie na plese\u0148 pomocou vitam\u00ednu D"},"content":{"rendered":"

Pod\u013ea v\u00fdskumn\u00edkov z Detskej nemocnice Lek\u00e1rskej fakulty Pittsburghskej univerzity, Lek\u00e1rskej fakulty Pittsburghskej univerzity a Lek\u00e1rskej fakulty Univerzity \u0161t\u00e1tu Louisiana,\u00a0 Vitam\u00edn D m\u00f4\u017ee by\u0165 efekt\u00edvnou terapiou na lie\u010dbu a prevenciu alergie na be\u017en\u00fa plese\u0148, ktor\u00e1 m\u00f4\u017ee sp\u00f4sobi\u0165 v\u00e1\u017ene komplik\u00e1cie pacientom s cystickou fibr\u00f3zou a astmou.<\/p>\n

V\u00fdsledky \u0161t\u00fadie, vedenej MUDr. Jayom Kollsom, Ph.D., pracovn\u00edkom v\u00fdskumu v oblasti p\u013e\u00facnych chor\u00f4b v Detskej nemocnici a profesorom pediatrie na Lek\u00e1rskej fakulte Pittsburghskej univerzity, boli publikovan\u00e9 v septembri 2010 v \u010dasopise Journal of Clinical Investigation.<\/p>\n

Aspergillus fumigatus je jedna z najbe\u017enej\u0161\u00edch vzdu\u0161n\u00fdch plesn\u00ed, a aj ke\u010f u ve\u013ekej v\u00e4\u010d\u0161iny t\u00fdch, ktor\u00ed ju vd\u00fdchnu, nesp\u00f4sob\u00ed ochorenie, u pacientov s cystickou fibr\u00f3zou m\u00f4\u017ee vyvola\u0165 \u017eivot ohrozuj\u00face alergick\u00e9 sympt\u00f3my . A\u017e u 15 percent pacientov s cystickou fibr\u00f3zou sa m\u00f4\u017ee prejavi\u0165 siln\u00e1 alergick\u00e1 reakcia, zn\u00e1ma ako alergick\u00e1 bronchopulmor\u00e1lna aspergil\u00f3za (ABPA). ABPA sa m\u00f4\u017ee prejavi\u0165 tie\u017e u niektor\u00fdch pacientov s astmou.<\/p>\n

V\u00fdskumn\u00fd t\u00edm veden\u00fd Dr. Kollom sk\u00famal pacientov s cystickou fibr\u00f3zou z Centra pre detsk\u00fa fibr\u00f3zu Antonia J. a Janet Palumbo v Detskej nemocnici, ktor\u00ed mali infekciu A. fumigatus. U jednej skupiny sa prejavila ABPA, k\u00fdm u druhej nie. V\u00fdskumn\u00edci zistili, \u017ee pacienti s ABPA mali zv\u00fd\u0161en\u00fa reakciu buniek imunitn\u00e9ho syst\u00e9mu, zn\u00e1mych ako T Helper 2 (Th2) a \u017ee pre t\u00fato zv\u00fd\u0161en\u00fa reakciu bol k\u013e\u00fa\u010dov\u00fd prote\u00edn OX40L . Zv\u00fd\u0161en\u00e1 reakcia Th2 korelovala s ni\u017e\u0161\u00edmi \u00farov\u0148ami vitam\u00ednu D v porovnan\u00ed s pacientmi, u ktor\u00fdch sa ABPA neprejavila. Pridanie vitam\u00ednu D do t\u00fdchto buniek v laborat\u00f3riu podstatne zn\u00ed\u017eilo expresiu OX40L a zv\u00fd\u0161ilo expresiu ostatn\u00fdch prote\u00ednov d\u00f4le\u017eit\u00fdch pre rozvoj tolerancie na alerg\u00e9ny.<\/p>\n

„Zistili sme, \u017ee dodanie vitam\u00ednu D podstatne zn\u00ed\u017eilo tvorbu prote\u00ednu, vyvol\u00e1vaj\u00faceho alergick\u00fa reakciu a tie\u017e zv\u00fd\u0161ilo tvorbu prote\u00ednu, ktor\u00fd podporuje toleranciu,“ povedal Dr. Kolls, ktor\u00fd je tie\u017e profesorom a ved\u00facim genetick\u00e9ho v\u00fdskumu v Centre medic\u00ednskych vied Univerzity \u0161t\u00e1tu Louisiana v New Orleans. „Na z\u00e1klade na\u0161ich v\u00fdsledkov m\u00e1me presved\u010div\u00e9 zd\u00f4vodnenie pre klinick\u00e9 testy vitam\u00ednu D, aby sme zistili, \u010di m\u00f4\u017ee p\u00f4sobi\u0165 pri prevencii alebo lie\u010dbe ABPA u pacientov s cystickou fibr\u00f3zou.“<\/p>\n

Cystick\u00e1 fibr\u00f3za je dedi\u010dn\u00e9 chronick\u00e9 ochorenie postihuj\u00face p\u013e\u00faca a tr\u00e1viaci syst\u00e9m, ktor\u00fdm pod\u013ea Nad\u00e1cie pre cystick\u00fa fibr\u00f3zu\u00a0 (CFF) trp\u00ed asi 30 000 det\u00ed a dospel\u00fdch v Spojen\u00fdch \u0161t\u00e1toch (70 000 na celom svete). Defektn\u00fd g\u00e9n a jeho prote\u00ednov\u00fd produkt sp\u00f4sobuj\u00fa, \u017ee telo produkuje mimoriadne hust\u00fd, lepkav\u00fd hlien, ktor\u00fd upch\u00e1va p\u013e\u00faca a vedie k \u017eivot ohrozuj\u00facim p\u013e\u00facnym infekci\u00e1m, blokuje v\u00fdvody pankreasu a br\u00e1ni vlastn\u00fdm tr\u00e1viacim enz\u00fdmom pri rozkladan\u00ed a tr\u00e1ven\u00ed potravy.<\/p>\n

D\u00f4le\u017eit\u00e9 zistenia t\u00edmu Dr. Kollsa prispievaj\u00fa k rast\u00facemu po\u010dtu d\u00f4kazov potvrdzuj\u00facich, \u017ee vitam\u00edn D m\u00f4\u017ee hra\u0165 v\u00fdznamn\u00fa \u00falohu pri imunitn\u00fdch reakci\u00e1ch a alergick\u00fdch chorob\u00e1ch, povedal MUDr. Juan Celed\u00f3n, Dr.P.H. ved\u00faci Oddelenia pre p\u013e\u00facnu medic\u00ednu, alergol\u00f3giu a imunol\u00f3giu Detskej nemocnice.<\/p>\n

Zdroj:\u00a0Marc Lukasiak,\u00a0University of Pittsburgh Schools of the Health Sciences,\u00a0http:\/\/www.medicalnewstoday.com\/articles\/199060.php<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Podľa výskumníkov z Detskej nemocnice Lekárskej fakulty Pittsburghskej univerzity, Lekárskej fakulty Pittsburghskej univerzity a Lekárskej fakulty Univerzity štátu Louisiana,  Vitamín D môže byť efektívnou terapiou na liečbu a prevenciu alergie na bežnú pleseň, ktorá môže spôsobiť vážne komplikácie pacientom s … Continued<\/a><\/p>\n","protected":false},"author":3,"featured_media":1600,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","footnotes":""},"categories":[3],"tags":[210,164],"class_list":["post-859","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lieky-a-liecba","tag-lieky","tag-vitamin-d"],"yoast_head":"\nPrevencia a lie\u010dba alergickej reakcie na plese\u0148 pomocou vitam\u00ednu D - Slan\u00e9 deti<\/title>\n<meta name=\"description\" content=\"Pod\u013ea vedcov m\u00f4\u017ee by\u0165 vitam\u00edn D efekt\u00edvnou terapiou na lie\u010dbu a prevenciu alergie na be\u017en\u00fa plese\u0148.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/slanedeti.sk\/cms\/prevencia-a-liecba-alergickej-reakcie-na-plesen-pomocou-vitaminu-d-2\/859\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prevencia a lie\u010dba alergickej reakcie na plese\u0148 pomocou vitam\u00ednu D - 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