{"id":854,"date":"2010-07-21T11:05:55","date_gmt":"2010-07-21T09:05:55","guid":{"rendered":"http:\/\/slanedeti.sk\/cms\/antibiotika-by-mohli-liecit-cysticku-fibrozu-2\/201007"},"modified":"2014-02-09T15:58:12","modified_gmt":"2014-02-09T14:58:12","slug":"antibiotika-by-mohli-liecit-cysticku-fibrozu-2","status":"publish","type":"post","link":"https:\/\/slanedeti.sk\/cms\/antibiotika-by-mohli-liecit-cysticku-fibrozu-2\/854","title":{"rendered":"Antibiotik\u00e1 by mohli lie\u010di\u0165 cystick\u00fa fibr\u00f3zu"},"content":{"rendered":"

Modifik\u00e1ciou gentamyc\u00ednu, be\u017ene pou\u017e\u00edvan\u00e9ho antibiotika, vyvinuli vedci na Technion-Izraelskom technologickom in\u0161tit\u00fate molekulu, ktor\u00e1 by mohla by\u0165 \u00fa\u010dinn\u00e1 pri lie\u010dbe mnoh\u00fdch \u013eudsk\u00fdch genetick\u00fdch ochoren\u00ed, vr\u00e1tane cystickej fibr\u00f3zy, Duchennovej muskul\u00e1rmej dystrofie, Usherovho syndr\u00f3mu, alebo viacer\u00fdch dedi\u010dn\u00fdch foriem rakoviny.<\/p>\n

Gentamyc\u00edn patr\u00ed do skupiny aminoglykozidov\u00fdch antibiot\u00edk, ktor\u00e9 sa pou\u017e\u00edvaj\u00fa na lie\u010dbu mnoh\u00fdch bakteri\u00e1lnych infekcii. \u0160t\u00fadie uk\u00e1zali \u017ee gentamyc\u00edn je schopn\u00fd napr\u00e1va\u0165 chyby, ktor\u00e9 vznikaj\u00fa v synt\u00e9ze prote\u00ednov pri genetick\u00fdch ochoreniach. Lie\u010divo pod\u013ea t\u00fdchto zisten\u00ed umo\u017e\u0148uje riboz\u00f3mom (bunkov\u00fdm \u0161trukt\u00faram zodpovedn\u00fdch za synt\u00e9zu prote\u00ednov) ignorova\u0165 poruchy a podpori\u0165 tvorbu plne funk\u010dn\u00fdch prote\u00ednov.<\/p>\n

Pou\u017eitie gentamyc\u00ednu si pri t\u00fdchto ochoreniach vy\u017eaduje omnoho vy\u0161\u0161ie d\u00e1vky ako s\u00fa be\u017ene predpisovan\u00e9 pri bakteri\u00e1lnych infekci\u00e1ch. V tak\u00fdch d\u00e1vkach je ale gentamyc\u00edn ve\u013emi toxick\u00fd a sp\u00f4sobuje trval\u00fa stratu sluchu (ototoxicitu), \u010do je z\u00e1sadn\u00fd ne\u017eiaduci \u00fa\u010dinok.<\/p>\n

Sp\u00f4sobom ako ob\u00eds\u0165 tieto komplik\u00e1cie je modifik\u00e1cia chemickej \u0161trukt\u00fary aminoglykozidov, v\u00fdvoj deriv\u00e1tu, s priaznivej\u0161\u00edmi biologick\u00fdmi a toxikologick\u00fdmi \u00fa\u010dinkami. Novou patentovanou molekulou ktor\u00e1 by mohla sp\u013a\u0148a\u0165 tieto po\u017eiadavky je deriv\u00e1t NB54, ktor\u00fd vyvinul t\u00edm pod veden\u00edm profesora Timora Baasova na Chemickej fakulte Technionu, Izraelskom technologickom in\u0161tit\u00fate.<\/p>\n

\u201cVytvorili sme nov\u00e9 pou\u017eitie pre aminoglykozidy, t\u00fdm \u017ee sme odstr\u00e1nili ich prirodzen\u00fa antibiotick\u00fa aktivitu\u201c,<\/em> vyjadril sa Baasov. \u201cV\u010faka strate antibiotickej aktivity s\u00fa vysoko selekt\u00edvne, menej toxick\u00e9 a umo\u017e\u0148uje to ich pou\u017eitie pri oprave prote\u00ednov z `nespr\u00e1vnych` \u013eudsk\u00fdch g\u00e9nov\u201c.<\/em><\/strong><\/p>\n

<\/em>Doteraz bol NB54 testovan\u00fd na bunkov\u00fdch kult\u00farach a vedci v s\u00fa\u010dasnosti \u010dakaj\u00fa na v\u00fdsledky testovania na zvierat\u00e1ch.\u00a0<\/span><\/strong>Tieto v\u00fdsledky boli publikovan\u00e9 23 marca 2009 v Journal of Medicinal Chemistry.<\/p>\n

Zdroj: Medical News Today, 8 apr\u00edl, 2009,\u00a0<\/em>http:\/\/www.medicalnewstoday.com\/articles\/145506.php<\/a><\/span><\/span><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Modifikáciou gentamycínu, bežne používaného antibiotika, vyvinuli vedci na Technion-Izraelskom technologickom inštitúte molekulu, ktorá by mohla byť účinná pri liečbe mnohých ľudských genetických ochorení, vrátane cystickej fibrózy, Duchennovej muskulármej dystrofie, Usherovho syndrómu, alebo viacerých dedičných foriem rakoviny. Gentamycín patrí do skupiny … Continued<\/a><\/p>\n","protected":false},"author":7,"featured_media":1600,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","footnotes":""},"categories":[3],"tags":[210],"class_list":["post-854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lieky-a-liecba","tag-lieky"],"yoast_head":"\nAntibiotik\u00e1 by mohli lie\u010di\u0165 cystick\u00fa fibr\u00f3zu - Slan\u00e9 deti<\/title>\n<meta name=\"description\" content=\"Modifik\u00e1ciou gentamyc\u00ednu, be\u017ene pou\u017e\u00edvan\u00e9ho antibiotika NB54, vyvinuli vedci molekulu, ktor\u00e1 by mohla by\u0165 \u00fa\u010dinn\u00e1 pri lie\u010dbe cystickej fibr\u00f3zy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/slanedeti.sk\/cms\/antibiotika-by-mohli-liecit-cysticku-fibrozu-2\/854\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Antibiotik\u00e1 by mohli lie\u010di\u0165 cystick\u00fa fibr\u00f3zu - 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