{"id":767,"date":"2010-06-10T16:04:20","date_gmt":"2010-06-10T14:04:20","guid":{"rendered":"http:\/\/slanedeti.sk\/cms\/prasa-kluc-k-liecbe-pluc-pacientov-s-cystickou-fibrozou-2\/201006"},"modified":"2014-02-09T15:59:07","modified_gmt":"2014-02-09T14:59:07","slug":"prasa-kluc-k-liecbe-pluc-pacientov-s-cystickou-fibrozou-2","status":"publish","type":"post","link":"https:\/\/slanedeti.sk\/cms\/prasa-kluc-k-liecbe-pluc-pacientov-s-cystickou-fibrozou-2\/767","title":{"rendered":"Prasa – k\u013e\u00fa\u010d k lie\u010dbe p\u013e\u00fac pacientov s cystickou fibr\u00f3zou"},"content":{"rendered":"

V\u010faka nov\u00e9mu experiment\u00e1lnemu modelu s\u00fa vedci o krok bli\u017e\u0161ie k pochopeniu pr\u00ed\u010diny vzniku p\u013e\u00facnych ochoren\u00ed u \u013eud\u00ed s CF.\u00a0 Z\u00e1very, publikovan\u00e9\u00a028. apr\u00edla 2010\u00a0v \u010dasopise Science Translational Medicine, by mohli pom\u00f4c\u0165 pri zdokona\u013eovan\u00ed lie\u010debn\u00fdch postupov pri ochoreniach p\u013e\u00fac, ktor\u00e9 b\u00fdvaj\u00fa pr\u00ed\u010dinou v\u00e4\u010d\u0161iny zhor\u0161en\u00fdch stavov a \u00famrt\u00ed pacientov s CF.<\/p>\n

Zd\u00e1 sa, \u017ee najm\u00e4 \u0161t\u00fadia realizovan\u00e1 vedeck\u00fdm t\u00edmom Univerzity \u0161t\u00e1tu Iowa (\u010falej UI) a ich kolegami z Univerzity \u0161t\u00e1tu Missouri je odpove\u010fou na dlho nezodpovedan\u00fa ot\u00e1zku o \u201esliepke a vajci\u201c, teda \u010di pri CF najprv doch\u00e1dza k infekcii alebo k z\u00e1palu p\u013e\u00fac.<\/p>\n

\u201ePomocou n\u00e1\u0161ho modelu za\u010d\u00edname na t\u00fato ot\u00e1zku nach\u00e1dza\u0165 odpove\u010f\u00a0 a vyzer\u00e1 to tak, akoby infekcia predch\u00e1dzala z\u00e1pal,\u201c povedal MUDr. David Stoltz, PhD., docent internej medic\u00edny na UI a ved\u00faci autor \u0161t\u00fadie. \u201eV\u00fdznam tohto zistenia spo\u010d\u00edva v tom, \u017ee by mohol ma\u0165 vplyv na typy lie\u010dby, ak\u00e9 by sme mohli pou\u017e\u00edva\u0165. Ke\u010f vieme, \u017ee prv\u00e1 prich\u00e1dza infekcia, m\u00f4\u017eeme jej pred\u00eds\u0165 alebo s \u0148ou bojova\u0165, \u010do by mohlo oddiali\u0165 alebo zabr\u00e1ni\u0165 ochoreniu p\u013e\u00fac u \u013eud\u00ed s CF.\u201c<\/p>\n

Zd\u00e1 sa napr\u00edklad, \u017ee zistenie\u00a0 podporuje v\u010dasn\u00fa a agres\u00edvnu lie\u010dbu p\u013e\u00facnych infekci\u00ed u det\u00ed s CF, dodal Stoltz, ktor\u00fd je aj z\u00e1stupcom riadite\u013ea CF centra pre dospel\u00fdch pacientov pri nemocniciach a klinik\u00e1ch UI.<\/p>\n

Ako nov\u00fd pokusn\u00fd model, ktor\u00fd Stoltz a jeho kolegovia pou\u017e\u00edvali, sl\u00fa\u017eilo prasa s g\u00e9novou mut\u00e1ciou, ktor\u00e1 sp\u00f4sobuje CF. T\u00edm vytvoril model, pri\u010dom pou\u017eil prasa, a d\u00fafal, \u017ee bude\u00a0 napodob\u0148ova\u0165 \u013eudsk\u00fa chorobu vernej\u0161ie, ne\u017e tomu bolo v pr\u00edpadoch, kde ako model sl\u00fa\u017eila my\u0161.<\/p>\n

Sk\u00faman\u00edm prasiat s CF po\u010das prv\u00fdch \u0161iestich mesiacov ich \u017eivota t\u00edm dok\u00e1zal, \u017ee sa u t\u00fdchto zvierat vyvinie p\u013e\u00facne ochorenie typu, ak\u00fd pozorujeme u \u013eud\u00ed, vr\u00e1tane infekcie v p\u013e\u00facach, z\u00e1palu, a hromadeniu hlienu v d\u00fdchac\u00edch cest\u00e1ch, \u010do je pre pacientov s CF z\u00e1va\u017en\u00fd probl\u00e9m.<\/p>\n

\u201eToto je skuto\u010dne skvel\u00fd pr\u00edklad prasiat sl\u00fa\u017eiacich ako model pre priebeh ochorenia u \u013eud\u00ed, a prasa reaguje na t\u00fato chorobu takmer rovnako,\u201c povedal Randall Prather, uzn\u00e1van\u00fd profesor reproduk\u010dnej biotechnol\u00f3gie na Univerzite \u0161t\u00e1tu Missouri. \u201eNaopak, ke\u010f pou\u017eijete my\u0161i, tie nedostan\u00fa p\u013e\u00facnu chorobu, be\u017en\u00fa u pacientov s cystickou fibr\u00f3zou.\u201c<\/p>\n

T\u00edm tie\u017e zistil, \u017ee p\u013e\u00faca pr\u00e1ve naroden\u00fdch prasiatok mali tendenciu sa infikova\u0165 v\u00e4\u010d\u0161\u00edm mno\u017estvom bakt\u00e9ri\u00ed ako p\u013e\u00faca kontroln\u00fdch prasiat. Navy\u0161e sa v priebehu nieko\u013ek\u00fdch hod\u00edn po naroden\u00ed uk\u00e1zalo, \u017ee prasiatka s CF vykazovali zn\u00e1mky toho, \u017ee ich p\u013e\u00faca maj\u00fa ni\u017e\u0161iu schopnos\u0165 zbavi\u0165 sa bakt\u00e9ri\u00ed, ktor\u00e9 sa im dostali do p\u013e\u00fac. Tento probl\u00e9m by mohol predstavova\u0165 po\u010diato\u010dn\u00fa f\u00e1zu v postupe ochorenia, ktor\u00e1 m\u00e1 za n\u00e1sledok chronick\u00fa infekciu p\u013e\u00fac u CF-k\u00e1rov.<\/p>\n

\u201eN\u00e1\u0161 nov\u00fd model n\u00e1m pom\u00f4\u017ee pochopi\u0165 mechanizmus ochorenia p\u013e\u00fac u \u013eud\u00ed s CF,\u201c povedal Stoltz. \u201ePoskytuje tie\u017e jedine\u010dn\u00fa pr\u00edle\u017eitos\u0165 vysk\u00fa\u0161a\u0165 r\u00f4zne sp\u00f4soby terapie, za\u010d\u00ednaj\u00fac od ve\u013emi skor\u00e9ho \u0161t\u00e1dia choroby \u2013 ove\u013ea sk\u00f4r, ako to m\u00f4\u017eeme robi\u0165 u \u013eud\u00ed \u2013 a mo\u017eno ur\u010di\u0165 prevent\u00edvne terapie, ktor\u00e9 by mohli pom\u00f4c\u0165 oddiali\u0165 alebo dokonca zabr\u00e1ni\u0165 tomu typu ochorenia p\u013e\u00fac, ktor\u00fd postihuje \u013eud\u00ed s CF.<\/p>\n

Okrem Stoltza a Prathera boli \u010dlenmi interdisciplin\u00e1rneho t\u00edmu vedci z UI Carver College of Medicine , UI College of Dentistry a z Univerzity \u0161t\u00e1tu Missouri. MUDr. Michael Welsh,\u00a0 profesor internej medic\u00edny a molekul\u00e1rnej fyziol\u00f3gie a biofyziky UI, \u0161\u00e9f katedry internej medic\u00edny a fyziol\u00f3gie a biofyziky na Roy J. Carver College, bol hlavn\u00fdm autorom \u0161t\u00fadie.<\/p>\n

\u0160t\u00fadia bola s\u010dasti financovan\u00e1 z grantov n\u00e1rodn\u00fdch zdravotn\u00fdch \u00fastavov a nad\u00e1cie cystickej fibr\u00f3zy.<\/p>\n

M. Welsh je spoluzakladate\u013eom Exemplar Genetics, spolo\u010dnosti vyd\u00e1vaj\u00facej licencie na materi\u00e1ly a technol\u00f3gie s\u00favisiace s touto pr\u00e1cou.<\/p>\n

Zdroj: University of Iowa,\u00a0<\/em>http:\/\/www.medicalnewstoday.com\/articles\/186995.php<\/em><\/a> <\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Vďaka novému experimentálnemu modelu sú vedci o krok bližšie k pochopeniu príčiny vzniku pľúcnych ochorení u ľudí s CF.  Závery, publikované 28. apríla 2010 v časopise Science Translational Medicine, by mohli pomôcť pri zdokonaľovaní liečebných postupov pri ochoreniach pľúc, ktoré bývajú príčinou … Continued<\/a><\/p>\n","protected":false},"author":3,"featured_media":1600,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","footnotes":""},"categories":[3],"tags":[19],"class_list":["post-767","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lieky-a-liecba","tag-liecba-pluc"],"yoast_head":"\nPrasa - k\u013e\u00fa\u010d k lie\u010dbe p\u013e\u00fac pacientov s cystickou fibr\u00f3zou - Slan\u00e9 deti<\/title>\n<meta name=\"description\" content=\"Z\u00e1very publikovan\u00e9 v \u010dasopise Science Translational Medicine, by mohli pom\u00f4c\u0165 pri zdokona\u013eovan\u00ed lie\u010debn\u00fdch postupov pri ochoreniach p\u013e\u00fac.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/slanedeti.sk\/cms\/prasa-kluc-k-liecbe-pluc-pacientov-s-cystickou-fibrozou-2\/767\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prasa - 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