{"id":2085,"date":"2019-12-08T11:05:46","date_gmt":"2019-12-08T10:05:46","guid":{"rendered":"http:\/\/slanedeti.sk\/cms\/?p=2085"},"modified":"2019-12-08T11:05:48","modified_gmt":"2019-12-08T10:05:48","slug":"najzaujimavejsie-prednasky-z-cf-konferencie","status":"publish","type":"post","link":"https:\/\/slanedeti.sk\/cms\/najzaujimavejsie-prednasky-z-cf-konferencie\/2085","title":{"rendered":"Najzauj\u00edmavej\u0161ie predn\u00e1\u0161ky z CF konferencie"},"content":{"rendered":"\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Koncom novembra sa v Novom\nSmokovci uskuto\u010dnila 11. slovensk\u00e1 CF\nkonferencia. Na konferencii bolo viacero predn\u00e1\u0161aj\u00facich a \u00fa\u010dastn\u00edkov aj z\nokolit\u00fdch kraj\u00edn, \u010d\u00edm konferencia z\u00edskava aj vy\u0161\u0161\u00ed v\u00fdznam v r\u00e1mci\nstredoeur\u00f3pskeho regi\u00f3nu. Konferencia reflektovala aktu\u00e1lne klinick\u00e9 t\u00e9my v\nlie\u010dbe cystickej fibr\u00f3zy, ako n\u00e1stup CFTR modul\u00e1torov, CF mikrobiol\u00f3giu,\nfyzioterapiu a&nbsp;\u010fal\u0161ie. Prin\u00e1\u0161ame stru\u010dn\u00fd preh\u013ead toho najd\u00f4le\u017eitej\u0161ieho.\nS\u00fa\u010das\u0165ou CF konferencie bola aj tla\u010dov\u00e1 konferencia, v\u010faka ktorej sa inform\u00e1cie\no&nbsp;cystickej fibr\u00f3ze objavili vo viacer\u00fdch m\u00e9di\u00e1ch (<a href=\"https:\/\/www.teraz.sk\/slovensko\/zdravie-situacia-s-liecbou-cystickej\/433026-clanok.html\">teraz.sk<\/a>, <a href=\"https:\/\/www.facebook.com\/cystickafibroza\/videos\/448617899370191\/\">RTVS<\/a>).<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Po ozn\u00e1men\u00ed schv\u00e1lenia\nrevolu\u010dn\u00e9ho lieku Trikafta v okt\u00f3bri, ako aj podan\u00ed \u017eiadosti Vertexu o\nkategoriz\u00e1ciu Orkambi v&nbsp;SR, je jednou s najdiskutovanej\u0161\u00edch t\u00e9m n\u00e1stup\nCFTR modul\u00e1torov a pr\u00edstup pacientov k tejto lie\u010dbe. Sk\u00fasenosti s lie\u010dbou CFTR\nmodul\u00e1tormi prezentovali lek\u00e1ri z CF centra z fakultnej nemocnice v pra\u017eskom\nMotole. Klinick\u00e9 \u0161t\u00fadie s CFTR modul\u00e1tormi sa tam za\u010dali v decembri 2009, tak\u017ee\nv s\u00fa\u010dasnosti disponuj\u00fa u\u017e 10-ro\u010dn\u00fdmi sk\u00fasenos\u0165ami. Najdlh\u0161ie sk\u00fasenosti s\u00fa v pra\u017eskom\ncentre samozrejme s ivakaftorom (Kalydecom), ktor\u00fd pri\u0161iel na trh ako prv\u00fd. V s\u00fa\u010dasnosti\nprebieha v Motole klinick\u00e1 \u0161t\u00fadia s najnov\u0161\u00edm liekom Trikafta. Celkovo prebehlo\nod r. 2009 v Motole 7 klinick\u00fdch \u0161t\u00fadii s modul\u00e1tormi. V posledn\u00fdch rokoch\nza\u010dali \u010desk\u00e9 zdravotn\u00e9 pois\u0165ovne na z\u00e1klade v\u00fdnimiek a \u0161peci\u00e1lnych programov\n\u010dasti pacientov, prepl\u00e1ca\u0165 lie\u010dbu CFTR modul\u00e1tormi, tak\u017ee sk\u00fasenosti s\u00fa aj so\n\u0161tandardnou lie\u010dbou (mimo klinick\u00fdch \u0161t\u00fadii). Po za\u010dat\u00ed lie\u010dby je pozorovan\u00fd\nn\u00e1rast p\u013e\u00facnych funkci\u00ed, ktor\u00fd je ve\u013emi v\u00fdrazn\u00fd pri Kalydecu a Trikafte (FEV1\nokolo 10 %), ni\u017e\u0161\u00ed pri Orkambi (4&nbsp;%). Po \u00favodnom n\u00e1raste nast\u00e1va\nstabiliz\u00e1cia tak, \u017ee nasleduj\u00facich 10 rokov u pozorovan\u00fdch pacientov nastalo\ntakmer zastavenie poklesu funkcie p\u013e\u00fac. P\u013e\u00facne funkcie s\u00fa najd\u00f4le\u017eitej\u0161\u00edm\nparametrom a markerom ochorenia. Klinick\u00fd v\u00fdznam lie\u010dby CFTR modul\u00e1tormi je\nv\u0161ak omnoho \u0161ir\u0161\u00ed ako len zlep\u0161enie funkcie p\u013e\u00fac. D\u00f4le\u017eit\u00e9 je v\u00fdrazn\u00e9 zn\u00ed\u017eenie\nexacerb\u00e1ci\u00ed a zn\u00ed\u017eenie hospitaliz\u00e1cii pribli\u017ene o 80&nbsp;%. Celkovo t\u00e1to\nlie\u010dba takmer zastavuje progresiu ochorenia. Podobn\u00fd priebeh po za\u010dat\u00ed lie\u010dby\nm\u00e1 aj BMI (Body Mass Index). Najprv prich\u00e1dza k jeho v\u00fdrazn\u00e9mu zv\u00fd\u0161eniu a jeho\n\u010fal\u0161\u00ed priebeh je menej stabiln\u00fd ako pri FEV1 \u2013 z\u00e1vis\u00ed od \u010fal\u0161\u00edch faktorov, aj\nke\u010f celkovo je tie\u017e v\u00fdrazne lep\u0161\u00ed ako u pacientov bez lie\u010dby modul\u00e1tormi.\nUveden\u00e9 benefity s\u00fa pribli\u017ene rovnak\u00e9 aj pri lie\u010dbe Orkambi, napriek tomu, \u017ee\nsa neprejavuj\u00fa tak v\u00fdrazne na zlep\u0161en\u00ed FEV1. U pacientov v Motole neboli\npozorovan\u00e9 \u017eiadne z\u00e1va\u017en\u00e9 ne\u017eiad\u00face \u00fa\u010dinky. U niektor\u00fdch pacientov do\u0161lo k\nmiernemu zhor\u0161eniu markerov pe\u010de\u0148ov\u00fdch funkcii, ale ich v\u00fdsledky boli st\u00e1le v\nr\u00e1mci normy.&nbsp;<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Indik\u00e1cia CFTR modul\u00e1torov\nje z\u00e1visl\u00e1 na type mut\u00e1cii u konkr\u00e9tneho pacienta. V tejto s\u00favislosti op\u00e4\u0165\nnadob\u00fada v\u00fdznam genetick\u00e9 testovanie pacientov, ke\u010f\u017ee je potrebn\u00e1 \u00fapln\u00e1 istota\npri nastaven\u00ed lie\u010dby, aby bol indikovan\u00fd spr\u00e1vny liek (vtedy, ke\u010f bude ma\u0165\npacient k nemu re\u00e1lny pr\u00edstup). Genetick\u00e9 vy\u0161etrenie u niektor\u00fdch pacientov\n(spravidla sa rob\u00ed pre potvrdenie diagn\u00f3zy) je star\u00e9 aj desa\u0165ro\u010dia, z obdobia,\nke\u010f nebolo mo\u017en\u00e9 detekova\u0165 v\u0161etky mut\u00e1cie. \u010eal\u0161ia n\u00e1mietka bola na kvalitu\nvy\u0161etren\u00ed niektor\u00fdch genetick\u00fdch laborat\u00f3ri\u00ed, ktor\u00fa na konferencii vyslovil\nsvetovo uzn\u00e1van\u00fd genetik prof. Macek. V \u010cR pri za\u010dat\u00ed lie\u010dby zdravotn\u00e1\npois\u0165ov\u0148a po\u017eaduje genetick\u00e9 vy\u0161etrenie z certifikovan\u00e9ho genetick\u00e9ho\nlaborat\u00f3ria.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto1-1024x768.jpg\" alt=\"cf_konferencia_foto1\" class=\"wp-image-2086\" srcset=\"https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto1-1024x768.jpg 1024w, https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto1-300x225.jpg 300w, https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto1-768x576.jpg 768w, https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto1.jpg 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Bolo pop\u00edsan\u00fdch okolo 2000\nmut\u00e1cii v CFTR g\u00e9ne, ktor\u00e9 vyvol\u00e1vaj\u00fa cystick\u00fa fibr\u00f3zu. Situ\u00e1cia, ke\u010f je mo\u017en\u00e9\nlie\u010di\u0165 iba pacientov s niektor\u00fdmi mut\u00e1ciami a z lie\u010dite\u013en\u00fdch mut\u00e1ci\u00ed ka\u017ed\u00fa in\u00fdm\nliekom, sa zd\u00e1 by\u0165 nepreh\u013eadn\u00e1. Za \u00fa\u010delom jej spreh\u013eadnenia bola vyvinut\u00e1\ndatab\u00e1za <a href=\"https:\/\/www.cftr2.org\/\">CFTR2<\/a> a tie\u017e mobiln\u00e1 aplik\u00e1cia <a href=\"https:\/\/www.cfgenee.com\/\">CF&nbsp;Gene&nbsp;E<\/a>. Pomocou oboch \u013eahko zist\u00edte, \u010di je dan\u00e1 mut\u00e1cia\nlie\u010dite\u013en\u00e1, a ktor\u00fdm liekom. CFTR2 poskytuje aj z\u00e1kladn\u00e9 \u0161tatistick\u00e9 \u00fadaje ku\nklinick\u00e9mu stavu pacientov s danou mut\u00e1ciou, \u010d\u00edm pripom\u00edna&nbsp;CF register.<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Prof. Macek prezentoval\njeho prebiehaj\u00faci v\u00fdskum v oblasti popula\u010dnej genetiky cystickej fobr\u00f3zy. V\u010faka\njeho pr\u00e1ci bol ur\u010den\u00fd genotyp v\u0161etk\u00fdch CF pacientov v \u010cR. V posledn\u00fdch rokoch\nanalyzoval genotypy CF pacientov z viacer\u00fdch kraj\u00edn strednej a v\u00fdchodnej Eur\u00f3py\na z Balk\u00e1nu. Tieto popul\u00e1cie boli omnoho menej pre\u0161tudovan\u00e9 ako z\u00e1padoeur\u00f3pske\npopul\u00e1cie, v\u010faka \u010domu op\u00edsal aj viacero \u00faplne nov\u00fdch mut\u00e1ci\u00ed. Oblas\u0165 strednej\nEur\u00f3py, ktor\u00e1 v minulosti tvorila Rak\u00fasko-Uhorsko (CZ, SK, HU, z\u00e1padn\u00e1 UA) m\u00e1\npodobn\u00e9 zlo\u017eenie a zast\u00fapenie CFTR mut\u00e1cii. Krajina s vysokou variabilitou a\ntie\u017e prechodom od stredoeur\u00f3pskeho charakteru zast\u00fapenia mut\u00e1ci\u00ed k\njuhoeur\u00f3pskemu je Rumunsko. Vplyv na to m\u00f4\u017ee ma\u0165 geografick\u00e1 izol\u00e1cia mnoh\u00fdch\npopul\u00e1ci\u00ed v hornatom ter\u00e9ne. V krajin\u00e1ch stredn\u00e9ho a ju\u017en\u00e9ho Balk\u00e1nu smerom na\njuh narast\u00e1 zast\u00fapenie typicky tureck\u00fdch mut\u00e1cii, \u010do m\u00e1 s\u00favislos\u0165 s tureckou\nnadvl\u00e1dou v t\u00fdchto oblastiach v dob\u00e1ch Osmanskej r\u00ed\u0161e. V r\u00e1mci slovenskej\npopul\u00e1cie je oproti okolit\u00fdm slovansk\u00fdm krajin\u00e1m o nie\u010do ni\u017e\u0161ie zast\u00fapenie\ntypicky slovansk\u00fdch mut\u00e1ci\u00ed a mierne viac s\u00fa zast\u00fapen\u00e9 p\u00f4vodom stredomorsk\u00e9\nmut\u00e1cie, \u010do zrejme s\u00favis\u00ed s roz\u0161\u00edren\u00edm R\u00edmskej r\u00ed\u0161e a\u017e k ju\u017en\u00fdm hraniciam\nSlovenska. V r\u00e1mci Slovenska (ako aj okolit\u00fdch kraj\u00edn) je odli\u0161n\u00e9 zast\u00fapenie\nCFTR mut\u00e1ci\u00ed u r\u00f3mskeho etnika, u ktor\u00e9ho sa cystick\u00e1 fibr\u00f3za vyskytuje omnoho\nzriedkavej\u0161ie oproti majoritnej popul\u00e1cii.&nbsp; Pravdepodobnos\u0165 narodenia\nchor\u00e9ho s&nbsp;cystickou fibr\u00f3zou je v r\u00f3mskej popul\u00e1cii pribli\u017ene 1:70000,\nzatia\u013e \u010do v majoritnej slovenskej popul\u00e1cii 1:5000.<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Met\u00f3dy genetickej\ndiagnostiky s\u00fa u\u017e be\u017ene zaveden\u00e9 v klinickej praxi a v\u010faka nim doch\u00e1dza k\nzni\u017eovaniu incidencie CF, v niektor\u00fdch krajin\u00e1ch a\u017e o 50&nbsp;%. Inak povedan\u00e9\nrod\u00ed sa menej det\u00ed s CF, ke\u010f\u017ee \u010das\u0165 bud\u00facich matiek podstupuje prenat\u00e1lne\ngenetick\u00e9 testovanie plodu a v pr\u00edpade genetick\u00fdch v\u00e1d sa m\u00f4\u017eu rozhodn\u00fa\u0165 pre\npreru\u0161enie tehotenstva. \u0160tandardne sa testuj\u00fa embry\u00e1 aj pri IVF (In vitro\nfertilisation) a taktie\u017e sa \u010dastej\u0161ie vykon\u00e1va tzv. prekoncep\u010dn\u00fd skr\u00edning \u2013\nosoby, ktor\u00e9 pl\u00e1nuj\u00fa splodi\u0165 potomstvo podst\u00fapia genetick\u00e9 vy\u0161etrenie. Na\ndruhej strane pokrokom v diagnostike bolo zavedenie novorodeneck\u00e9ho skr\u00edningu \u2013\nve\u013ek\u00e1 v\u00e4\u010d\u0161ina CF pacientov je diagnostikovan\u00e1 kr\u00e1tko po naroden\u00ed a v\u010faka\nskor\u00e9mu n\u00e1stupu lie\u010dby je ich pre\u017e\u00edvanie lep\u0161ie, \u010do dokazuje porovnanie kohorty\nnovorodeneck\u00e9ho skr\u00edningu, oproti de\u0165om bez skr\u00edningu. Aj ke\u010f je spo\u013eahlivos\u0165\nskr\u00edningu vysok\u00e1, nie je absol\u00fatna. Na Slovensku bolo zisten\u00fdch za uplynul\u00fdch\n10 rokov 6 pr\u00edpadov falo\u0161ne negat\u00edvneho v\u00fdsledku novorodeneck\u00e9ho skr\u00edningu pre\nCF. Teda pr\u00edpadov, ke\u010f skr\u00edning u die\u0165a\u0165a nezistil CF, ale nesk\u00f4r bolo\ndiagnostikovan\u00e9 na z\u00e1klade klinick\u00fdch pr\u00edznakov.<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Jedna z prezent\u00e1cii\nopisovala kazuistiku tehotnej CF pacientky z CF centra z Ko\u0161\u00edc. S tehotenstvom\nu CF pacientiek sa stretli lek\u00e1ri u\u017e vo v\u0161etk\u00fdch troch slovensk\u00fdch CF centr\u00e1ch.\nPlodnos\u0165 je u v\u00e4\u010d\u0161iny \u017eien s CF zachovan\u00e1, ale iba relat\u00edvne mal\u00e1 \u010das\u0165 z nich\nm\u00e1 deti. Tehotenstv\u00e1 CF pacientiek v\u0161ak u\u017e dlh\u0161iu dobu nie s\u00fa vo svete ni\u010d\u00edm\nv\u00fdnimo\u010dn\u00fdm a o ich priebehu je u\u017e dostatok medic\u00ednskych poznatkov. Pri tehotenstve\nje potrebn\u00e1 \u00faprava lie\u010debn\u00e9ho re\u017eimu, napr\u00edklad pod\u00e1vania liekov tak, aby nebol\nohrozen\u00fd plod. Tehotenstvo (aj doj\u010denie) predstavuje samozrejme pre organizmus\n\u010fal\u0161iu z\u00e1\u0165a\u017e. Doch\u00e1dza napr. k (prechodn\u00e9mu) zn\u00ed\u017eeniu p\u013e\u00facnych objemov a\nzv\u00fd\u0161eniu n\u00e1rokov na v\u00fd\u017eivu. Z t\u00fdchto d\u00f4vodov sa tehotenstvo neodpor\u00fa\u010da pacientkam\ns nepriazniv\u00fdm zdravotn\u00fdm stavom, v z\u00e1ujme ochrany zdravia matky ako aj plodu.\nZa kontraindik\u00e1ciu tehotenstva sa pova\u017euj\u00fa niektor\u00e9 z nasleduj\u00facich\nparametrov:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>koloniz\u00e1cia\n     Burkholderiou cepacia<\/li><li>BMI\n     ni\u017e\u0161ie ako 18<\/li><li>FVC\n     alebo FEV1 pod 50&nbsp;%<\/li><\/ul>\n\n\n\n<p>Odborn\u00e9 odpor\u00fa\u010danie lek\u00e1ra je v\u017edy len odpor\u00fa\u010dan\u00edm. Lek\u00e1r nem\u00e1 \u017eiadnu\nmo\u017enos\u0165 pacientke tehotenstvo \u201ezak\u00e1za\u0165\u201c. T\u00e1to kazuistika prezentovala pr\u00edpad\npacientky, ktor\u00e1 nesp\u013a\u0148ala zdravotn\u00e9 krit\u00e9ri\u00e1 pre bezpe\u010dn\u00fd priebeh tehotenstva\na napriek tomu sa pre\u0148ho rozhodla. P\u00e1r pl\u00e1noval potomstvo, pre oplodnenie bolo\npotrebn\u00e9 IVF. Po\u010das tohto tehotenstva sa ale neobjavili v\u00e1\u017ene komplik\u00e1cie a\nnakoniec pacientka porodila zdrav\u00e9 die\u0165a.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto2-1024x768.jpg\" alt=\"cf_konferencia_foto2\" class=\"wp-image-2087\" srcset=\"https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto2-1024x768.jpg 1024w, https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto2-300x225.jpg 300w, https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto2-768x576.jpg 768w, https:\/\/slanedeti.sk\/cms\/wp-content\/uploads\/2019\/12\/cf_konferencia_foto2.jpg 1500w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Jednou z t\u00e9m, ktorej sa\nvenovala na konferencii pozornos\u0165 bola tie\u017e fyzioterapia. Boli prezentovan\u00e9\npozit\u00edvne sk\u00fasenosti s pr\u00edstrojom <a href=\"https:\/\/www.mr-diagnostic.cz\/simeox\">simeox<\/a>, ktor\u00fd napom\u00e1ha\nodhlieneniu doln\u00fdch d\u00fdchac\u00edch ciest. Pr\u00edstroj maj\u00fa napr\u00edklad v CF centre v\nBanskej Bystrici a u pacientov viedlo jeho pou\u017e\u00edvanie k zlep\u0161eniu p\u013e\u00facnych\nfunkci\u00ed. Jedn\u00e1 sa o novinku, v bud\u00facnosti prich\u00e1dza do \u00favahy aj jeho vyu\u017eitie v\ndom\u00e1cej lie\u010dbe.<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Na konferencii vyst\u00fapila\naj Michaela \u0160\u00edpekov\u00e1, ktor\u00e1 tlmo\u010dila stanovisko dospel\u00fdch CF pacientov. S\u00fa\u010dasn\u00fd\nstav v SR podrobila ostrej kritike, \u010do ilustruje aj skuto\u010dnos\u0165, \u017ee v tomto\nroku&nbsp;zomrelo u\u017e 12 pacientov s&nbsp;cystickou fibr\u00f3zou. Nastupuj\u00face\nprobl\u00e9my, ako s\u00fa napr\u00edklad poddimenzovan\u00e9 person\u00e1lne obsadenie CF centier,\nn\u00e1rast antibiotickej rezistencie, zastaral\u00e1 legislat\u00edva, ktor\u00e1 pova\u017eovala CF\niba za detsk\u00e9 ochorenie znamenaj\u00fa, \u017ee zdravotn\u00edcka starostlivos\u0165 o dospel\u00fdch CF\npacientov sa v niektor\u00fdch oblastiach miesto zlep\u0161ovania mo\u017eno aj zhor\u0161uje a\njednozna\u010dne zaost\u00e1va za \u0161tandardmi EU. Pacienti jednozna\u010dne podporuj\u00fa pr\u00e1vo na\npr\u00edstup k inovat\u00edvnej lie\u010dbe \u2013 najm\u00e4 CFTR modul\u00e1torom, pre mnoh\u00fdch z nich je to\ndoslovne ot\u00e1zka pre\u017eitia.<\/p>\n\n\n\n<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Na konferenciu pri\u0161iel aj\ntvorca aplik\u00e1cie <a href=\"https:\/\/play.google.com\/store\/apps\/details?id=com.cfhero.android&amp;gl=SK\">CF Hero<\/a>, ktor\u00e1 je\nur\u010den\u00e1 pre teenagerov s CF. Aplik\u00e1cia m\u00e1 viacstrann\u00fa funkcionalitu, od\nnavedenia k spr\u00e1vnemu inhalovaniu a\u017e po hrav\u00e9 a soci\u00e1lne prvky. Po \u010deskej a\nslovenskej autor v s\u00fa\u010dasnosti pracuje na anglickej verzii.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Koncom novembra sa v Novom Smokovci uskuto&#269;nila 11. slovensk&aacute; CF konferencia. Na konferencii bolo viacero predn&aacute;&scaron;aj&uacute;cich a &uacute;&#269;astn&iacute;kov aj z okolit&yacute;ch kraj&iacute;n, &#269;&iacute;m konferencia z&iacute;skava aj vy&scaron;&scaron;&iacute; v&yacute;znam v r&aacute;mci stredoeur&oacute;pskeho regi&oacute;nu. Konferencia reflektovala aktu&aacute;lne klinick&eacute; t&eacute;my v lie&#269;be &hellip; <a href=\"https:\/\/slanedeti.sk\/cms\/najzaujimavejsie-prednasky-z-cf-konferencie\/2085\">Continued<\/a><\/p>\n","protected":false},"author":7,"featured_media":2088,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"kt_blocks_editor_width":"","footnotes":""},"categories":[2,3],"tags":[],"class_list":["post-2085","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informacie","category-lieky-a-liecba"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Najzauj\u00edmavej\u0161ie predn\u00e1\u0161ky z CF konferencie - Slan\u00e9 deti<\/title>\n<meta name=\"description\" content=\"Konferencia reflektovala aktu\u00e1lne klinick\u00e9 t\u00e9my v lie\u010dbe cystickej fibr\u00f3zy, ako n\u00e1stup CFTR modul\u00e1torov, CF mikrobiol\u00f3giu, fyzioterapiu a \u010fal\u0161ie. 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